P-104: The Effect of L-Carnitine on Mouse Transplanted Ovarian Tissue

Background The aim of this study was to evaluate the effect of L-carnitine as an antioxidant on transplantation of ovarian tissue. MaterialsAndMethods Ovaries from 6-week old mice were grafted into back muscle. Transplanted ovaries were divided into three groups. 150 mg/Kg LC (solved in normal saline) was injected intraperitoneally one hour before surgical operation and repeated one other day until 21 days. Follicular morphology and apoptosis were examined in all groups and compared to age-matched non grafted ovaries. Anti procaspase-3 antibody was used to evaluate apoptosis in all groups.9 Results Morphological analysis revealed that the number of follicles decreased in all transplanted groups in comparison with non grafted ones.The percentage of normal and degenerative follicles in all developmental stages had no significant differences. The rate of apoptosis in all groups had no significant differences9 Conclusion It seems that this concentration of LC have no effect on morphological and apoptosis of follicles in grafted ovaries. However, further studies are required for the fertilization rate of oocytes.���